|
KMID : 0525720120170030147
|
|
Journal of Chitin and Chitosan
2012 Volume.17 No. 3 p.147 ~ p.151
|
|
|
Preparation and Antibacterial Activity of Valine- and Lysine-grafted O-Carboxymethyl Chitosan
|
|
Kim Jun-Ho
Lee Kyoung-Jae
Nam Joung-Pyo
Choi Chang-Yong
Park Seong-Cheol
Jang Mi-Kyeong
Nah Jae-Woon
|
|
|
Abstract
|
|
|
|
In general, low molecular weight water-soluble chitosan (LMWSC) has a weak antibacterial activity against pathogenic bacteria in physiological condition, because its cationicity acquired by amine group is less than high molecular weight chitosan (HMWC) and is reduced in salt condition. In addition, hydrophobic moiety is essential to increase antibacterial activity due to membranolytic action of chitosan. The aim of this study is to prepare the modified LMWSCs with a strong antibacterial activity in physiological condition. In order to hydrophobicity or cationicity, valine which is a hydrophobic amino acid or lysine which is a cationic amino acid, respectively, was conjugated to O-carboxymethyl group of LMWSC by increasing the grafting amount of amino acids. The structure were investigated by fourier transform infrared (FT-IR), 1proton nuclear magnetic resonance (1HNMR). Antibacterial activity of lysine-grafted LMWSC was more enhanced than valine-grafted LMWSC. The results proposed that amino acid-grafted chitosan has a potential as an effective antibiotic material.
|
|
|
KEYWORD
|
|
|
Carboxylation chitosan, Amino acid, Antibacterial activity, Antibiotic
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|